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Change Check

Your medicine has a new dose. Find everything that still says the old one.

When a medicine's prescribing information changes, a Change Check finds the brochures, slides, emails, web pages and letters to doctors that still say the old version, and checks what AI tools tell doctors.

The prescribing information, which people in pharma call the label, is the official document a regulator approves for each medicine: the FDA in the US, the European Commission or a national agency in Europe, the MHRA in the UK.

Sample check

Start here
  • You send nothing, only the name of one medicine and the country.
  • We check your public websites and what five AI tools tell doctors.
  • You get a short report within five business days, and a 30-minute call.

Full Change Check

With early customers
  • You send your approved messages, your list of materials and your letters to doctors.
  • We check every brochure, slide, email, web page and letter, and five AI tools.
  • You get one list of what to update, withdraw or check, with the proof for each item.
How a full Change Check works

Check one of your medicines

Name a medicine whose prescribing information changed in the last twelve months. We start with the sample check, from public information only.

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An example

One list of everything that still says the old dose.

In this example, the fictional medicine Varigel gets a new dose. People with kidney problems should now take no more than 15 mg, down from 20 mg, and severe kidney disease is now listed under who should not take it. The check finds 35 items that still say the old version, inside the company and in AI answers.

Example view. Varigel is a fictional medicine and every figure is invented.

Where it looks

Six places the old version can still be.

What changed

The old and new prescribing information side by side, with the old and new wording of each part that changed.

Key messages

Every approved statement your company makes about the medicine that relies on a part that changed.

Sources

The studies and documents your materials cite. We flag any that still point to the old version of the prescribing information.

Brochures, slides, emails and web pages

Every piece of material that uses an affected message. Matching is by meaning, so reworded, rounded and translated copies are found too.

Letters to doctors

The medical information letters your team sends when doctors ask questions, from the set you share for the medicine.

Public pages and AI answers

Your websites for doctors and patients, and what ChatGPT, Gemini, Perplexity, Claude and Google AI Overviews say when asked about the change.

How it works

How a full Change Check works.

One medicine and one country at a time. The Juncture team runs it alongside your normal review, so you can compare what Juncture found with what your team found.

  1. 1

    Read both versions

    We take the old and the new prescribing information, from you or from the regulator's public website, and list exactly what changed.

  2. 2

    Find everything that relies on it

    We find every key message that relies on a changed part, then every brochure, slide, email, web page and letter that uses it, including reworded and translated copies.

  3. 3

    Check what AI tools tell doctors

    We ask five AI tools the questions doctors ask about the change. Answers that still give the old information are flagged, with the page they cite.

  4. 4

    Give your team one list

    Every item comes with the proof and a suggested action: update, withdraw or check. Your reviewers decide, and can attach the report in the review system you already use.

Early customers

What a full Change Check covers.

We run full Change Checks with a small number of early customers. Each one is set up the same way, so you know what you are agreeing to before we start.

One medicine
A medicine you choose, with its approved key messages, its list of materials and the letters your medical information team sends to doctors.
One country or region
The US, the EU or the UK, so the check works from one version of the prescribing information.
One recent or upcoming change
A change approved in the last twelve months, or one you expect soon. For an upcoming change we work from the proposed wording you share.
Alongside your normal review
Your team checks the same change the way it always does. We run ours, and you compare what each found.
Fits the system you use
Your reviewers can attach the report to the record in the review system you already use.

What you send

  • The old and new prescribing information, or we take them from the regulator's public website.
  • Your approved key messages and list of materials, exported from your review system.
  • The standard letters your medical information team sends to doctors about the medicine.

What you get

One list of everything that still says the old version: key messages, sources, materials, letters and AI answers. Each item has the proof and a suggested action for your reviewers: update, withdraw or check.

Why timing matters

Once a new version is approved, the old material has to catch up.

Promotional material must be consistent with the prescribing information. When the prescribing information changes, everything that relies on the old version has to be updated, and the record of what changed is public.

EU law

Advertising has to follow the official information

In Europe, all advertising for a medicine must comply with its official information (Directive 2001/83/EC, Article 87(2)). When the official information changes, the advertising has to change with it.

Read Article 87

US regulation

Anyone can see what changed, and when

In the US, major changes are listed at the top of the prescribing information for at least a year (21 CFR 201.57). Each one shows the month and year of the change, so out-of-date material is easy to spot.

Read 21 CFR 201.57

A UK case

Old material was withdrawn after 79 days

A drug company only withdrew its old promotional material 79 days after a new warning about who should not take the medicine was approved. Its safety training materials had not been updated, and seven pieces linked to a website without the current prescribing information. The PMCPA, which runs the UK industry code, publicly reprimanded the company's UK and European arms.

Read the case (PMCPA AUTH/3041/6/18)

What a Change Check never does

  • Approve, reject or edit your material. Your reviewers decide and make the changes.
  • Replace the review system or the review process you already use.
  • Send your material to AI tools. Only public, doctor-style questions go to them.
  • Change what AI tools say. It reports what they say and where they learned it.

Questions

Questions about the Change Check.

What is a Change Check?
Juncture's check for one medicine in one country after its prescribing information changes. We list what changed, find every key message, source, brochure, slide, email, web page and medical information letter that relies on it, check what AI tools say about it, and give your team one list with the proof and a suggested action for each item.
What is the prescribing information, or the label?
It is the medicine's official document, approved by a regulator such as the FDA in the US, the EMA or European Commission in Europe, or the MHRA in the UK. It says what the medicine treats, the dose, who should not take it, the warnings and the side effects. In the US it is often called the USPI and in Europe the SmPC. People in pharma call it the label.
What do we get from the sample check?
A short report on one of your medicines, built from public information only, and a 30-minute call. You name a medicine whose prescribing information changed in the last twelve months and the country. We read the public record of the change, check your public websites for doctors and patients and what five AI tools say, and list every public statement that still says the old version, with where we found it. You get it within five business days. You send nothing.
Where does the sample check find the public record of the change?
In the US, major changes are listed at the top of the prescribing information for at least a year (21 CFR 201.57), and past versions are public on Drugs@FDA and DailyMed. In Europe the EMA publishes each update. In the UK, the emc publishes the current version.
Do we run it ourselves?
No. The Juncture team runs each Change Check on the Juncture platform. We walk your team through the report, and your reviewers decide on every item.
What do we send for a full Change Check?
The old and new prescribing information, or we take them from DailyMed, the EMA or the emc. Your approved key messages and list of materials, as exported from your review system, such as Veeva PromoMats or Aprimo. The standard letters your medical information team sends to doctors about the medicine. Your review process stays as it is.
Our review system already shows where a message is used. What does this add?
Review systems track the links they hold, and a Change Check runs beside them. Because matching is by meaning, it also finds reworded, rounded and translated copies of an affected message. It also looks past your promotional library at letters to doctors, public pages and AI answers. Your reviewers can attach the report to the record in your system.
Can Juncture change what AI tools say?
No. Juncture reports what AI tools say about your medicine and which pages they learned it from. Your team decides what to update on your own pages.
Is our material used to train AI?
No. Your material is never used to train AI models. Juncture runs on Microsoft Azure with an EU region available, and the AI tools a Change Check looks at only receive public, doctor-style questions.

Start with one medicine

Pick one medicine whose prescribing information changed in the last year.

Start with the sample check from public information, or talk to us about a full Change Check on your own materials.

Check one of your medicinesBook a walkthrough